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How Messing With Our Body Clocks Can Raise Alarms With Health

Research that helped discover the clocks running in every cell in our bodies earned three scientists a Nobel Prize in medicine on Monday.

"With exquisite precision, our inner clock adapts our physiology to the dramatically different phases of the day," the Nobel Prize committee wrote of the work of Jeffrey C. Hall, Michael Rosbash and Michael W. Young. "The clock regulates critical functions such as behavior, hormone levels, sleep, body temperature and metabolism."

We humans are time-keeping machines. And it seems we need regular sleeping and eating schedules to keep all of our clocks in sync.

Studies show that if we mess with the body's natural sleep-wake cycle — say, by working an overnight shift, taking a trans-Aatlantic flight or staying up all night with a new baby or puppy — we pay the price.

Our blood pressure goes up, hunger hormones get thrown off and blood sugar control goes south.

We can all recover from an occasional all-nighter, an episode of jet lag or short-term disruptions.

But over time, if living against the clock becomes a way of life, this may set the stage for weight gain and metabolic diseases such as Type 2 diabetes.

"What happens is that you get a total de-synchronization of the clocks within us," explains Fred Turek, a circadian scientist at Northwestern University. "Which may be underlying the chronic diseases we face in our society today."

So consider what happens, for instance, if we eat late or in the middle of the night. The master clock — which is set by the light-dark cycle — is cuing all other clocks in the body that it's night. Time to rest.

"The clock in the brain is sending signals saying: Do not eat, do not eat!" says Turek.

But when we override this signal and eat anyway, the clock in the pancreas, for instance, has to start releasing insulin to deal with the meal. And, research suggests, this late-night munching may start to reset the clock in the organ. The result? Competing time cues.

"The pancreas is listening to signals related to food intake. But that's out of sync with what the brain is telling it to do," says Turek. "So if we're sending signals to those organs at the wrong time of day — such as eating at the wrong time of day — [we're] upsetting the balance."

And there's accumulating evidence that we may be more sensitive to these timing cues than scientists ever imagined.

Consider, for instance, the results of a weight-loss study that we reported on, which was published in 2013 in the International Journal of Obesity. Researchers found that the timing of meals can influence how much weight people lose.

"The finding that we had was that people who ate their main meal earlier in the day were much more successful at losing weight," says study author Frank Scheer, a Harvard neuroscientist who directs the Medical Chronobiology Program at Brigham and Women's Hospital.

In fact, early eaters lost 25 percent more weight than later eaters — "a surprisingly large difference," Scheer says. Another study found that eating a big breakfast was more conducive to weight loss, compared with a big dinner — adding to the evidence that the timing of meals is important.

Beyond weight management, there's evidence that the clocks in our bodies — and the timing of our sleeping, eating and activities — play multiple roles in helping us maintain good health. And different systems in the body are programmed to do different tasks at different times.

For instance, doctors have long known that the time of day you take a drug can influence its potency. "If you take a drug at one time of day, it might be much more toxic than another time of day," Turek says. Part of this effect could be that the liver is better at detoxifying at certain times of day.

Turek says his hope is that, down the road, circadian science will be integrated into the practice of medicine.

"We'd like to be in a position where we'd be able to monitor hundreds of different rhythms in your body and see if they're out of sync — and then try to normalize them," Turek says.

Whether — or how quickly — this may happen is hard to say. But what's clear is that the study of the biology of time is exploding.

"What we're doing now in medicine is what Einstein did for physics," says Turek. "He brought time to physics. We're bringing time to biology."

The irony, of course, is that this insight comes at a time when the demands of our 24/7 society mean more and more of us are overriding our internal clocks.

A previous version of this story was published in 2015.

Copyright 2017 NPR. To see more, visit http://www.npr.org/.

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